Man's Best Friend
A genetic research facility worker exposes animal abuses there to a local TV reporter, who frees and takes in a genetically altered dog from the lab, unaware that he has a violent streak.
Movies Like Man's Best Friend
Similar in style, tone, and themes — find your next watch.
Splinter
2008★ 6.2
When their plans for a nature trip go awry, Polly and boyfriend Seth decide to check into a motel. On their way, they're carjacked and kidnapped by low-rent crooks Dennis and Lacey, who take the victims and their SUV to a nearby gas station. Along the way, they encounter an increasingly terrifying horde of parasites, and if any of them intend to survive, they'll have to outsmart the deadly organisms.
Man-Made Monster
1941★ 6.2
Mad scientist turns a man into an electrically-controlled monster to do his bidding.
Replicant
2001★ 5.8
Scientists create a genetic clone of a serial killer in order to help catch the killer, teaming up with two cops.
Werewolves
2024★ 5.8
A year after a supermoon’s light activated a dormant gene, transforming humans into bloodthirsty werewolves and causing nearly a billion deaths, the nightmare resurfaces as the supermoon rises again. Two scientists attempt to stop the mutation but fail and must now struggle to reach one of their family homes.
The Dogs
2025★ 6.6
After fleeing his psychotic father, a young teen and his mom seek refuge in a remote farmhouse, only to face a pack of ferocious dogs and the sinister spirits that haunt the property.
Splice
2010★ 5.9
Elsa and Clive, two young rebellious scientists, defy legal and ethical boundaries and forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named "Dren", the creature rapidly develops from a deformed female infant into a beautiful but dangerous winged human-chimera, who forges a bond with both of her creators - only to have that bond turn deadly.
Deep Blue Sea
1999★ 6.0
Researchers on the undersea lab Aquatica have genetically altered the brains of captive sharks to develop a cure for Alzheimer's disease. But there's an unexpected side effect: the sharks got smarter, faster, and more dangerous. After a big storm damages their remote research facility, they must fight for their lives.
Slither
2006★ 6.5
A small town is taken over by an alien plague, turning residents into zombies and all forms of mutant monsters.
Alligator
1980★ 6.0
A baby alligator is flushed down a toilet and survives by eating discarded lab animals that have been injected with growth hormones. The now gigantic animal escapes the city sewers and goes on a rampage, pursued by a cop and a big-game hunter.
Assimilate
2019★ 6.3
Three friends making a web series about their town discover that their neighbors are being killed and replaced by creatures who are perfect copies of their victims.
The Voices
2014★ 6.3
A mentally unhinged factory worker must decide whether to listen to his talking cat and become a killer, or follow his dog's advice to keep striving for normalcy.
Die Alone
2024★ 6.3
Lost in a world reclaimed by nature and overrun by mysterious creatures, Ethan, a young man with amnesia navigates the dangerous landscape in search of his lost love Emma. His journey takes an unexpected turn when he encounters Mae, a hardened and eccentric survivor. Together, Ethan and Mae face threats both human and otherwise before a fateful encounter with Kai unravels a secret that lies just beyond Ethan's fractured memory.
M3GAN
2022★ 7.0
A brilliant toy company roboticist uses artificial intelligence to develop M3GAN, a life-like doll programmed to emotionally bond with her newly orphaned niece. But when the doll's programming works too well, she becomes overprotective of her new friend with terrifying results.
Resident Evil
2002★ 6.7
When a virus leaks from a top-secret facility, turning all resident researchers into ravenous zombies and their lab animals into mutated hounds from hell, the government sends in an elite military task force to contain the outbreak.
Hollow Man
2000★ 6.0
Cocky researcher Sebastian Caine is working on a project to make living creatures invisible. Determined to achieve the ultimate breakthrough, Caine pushes his team to move to the next phase — using himself as the subject. The test is a success, but when the process can't be reversed and Caine seems doomed to future without flesh, he starts to turn increasingly dangerous.
Land of the Dead
2005★ 6.3
The living dead have taken over the world, and the remaining humans live in a walled city to protect themselves as they cope with the situation.
Tremors 2: Aftershocks
1996★ 6.4
Earl Bassett's celebrity after defeating the Graboid attack against the town of Perfection has proved short-lived, until he's recruited by a Mexican oil company whose workers have found more than they bargained for under the soil.
The Brood
1979★ 6.7
A man tries to uncover an unconventional psychologist's therapy techniques on his institutionalised wife, amidst a series of brutal murders.
Subservience
2024★ 6.6
With his wife out sick, a struggling father brings home a lifelike AI, only to have his self-aware new help want everything her new family has to offer... Like the affection of her owner and she'll kill to get it.
Containment
2015★ 6.0
Neighbors in a block wake one morning to find they have been sealed inside their apartments. Can they work together to find out why? Or will they destroy each other in their fight to escape?